Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration Short Title: CD13 processes CXCL11
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چکیده
Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration Short Title: CD13 processes CXCL11 Paul Proost, Anneleen Mortier, Tamara Loos, Jo Vandercappellen, Mieke Gouwy, Isabelle Ronsse, Evemie Schutyser, Willy Put, Marc Parmentier, Sofie Struyf and Jo Van Damme Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Leuven, Belgium IRIBHN, Université Libre de Bruxelles, Brussels, Belgium Corresponding author: Paul Proost, Lab. Molecular Immunology, Rega Institute, K.U.Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Tel.: 32-16-337341; Fax.: 32-16-337340; email: [email protected] Blood First Edition Paper, prepublished online March 15, 2007; DOI 10.1182/blood-2006-10-049072
منابع مشابه
Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration.
CXCR3 ligands were secreted by tissue fibroblasts and peripheral blood-derived mononuclear leukocytes in response to interferon-gamma (IFN-gamma) and Toll-like receptor (TLR) ligands. Subsequent purification and identification revealed the presence of truncated CXCL11 variants missing up to 6 amino acids. In combination with CD26/dipeptidyl peptidase IV, the metalloprotease aminopeptidase N (AP...
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